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The TSP motif in AP180 inhibits phospholipase D1 activity resulting in increased efficacy of anticancer drug via its direct binding to carboxyl terminal of phospholipase D1

Signal TransductionSignaling PathwayBiochemistryPhospholipase D1MedicineAnticancer DrugApoptosisReceptor Tyrosine KinaseProtein PhosphorylationTsp MotifPharmacologyCell SignalingTumor BiologyDrug Discovery