Organocatalytic Conjugate Addition of Formaldehyde <i>N,N</i>-Dialkylhydrazones to β<i>,</i>γ-Unsaturated α-Keto Esters

Abstract

(1S,2R)-1-Aminoindan-2-ol-derived thioureas behave as efficient H-bonding organocatalysts for the nucleophilic conjugate addition of formaldehyde hydrazones to beta,gamma-unsaturated alpha-keto esters as enoate surrogates, affording the corresponding adducts in good yields and enantioselectivities.