Surgical pain attenuates acute morphine tolerance in rats

Ethical guidelines for investigations of experimental pain in conscious animals

M. Zimmermann · Pain · 1983 · 7.8K citations

Medicine, Anesthesiology, Animal Sciences +14

The Tragedy of Needless Pain

Ronald Melzack · Scientific American · 1990 · 430 citations

Nursing, Anatomy, Pain Management +4

Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.

Essam E. Abdelhamid, Marjia Sultana, Philip S. Portoghese et al. · Journal of Pharmacology and Experimental Therapeutics · 1991 · 427 citations

Medicine, Pharmacology, Neuropharmacology +16

A long-term survey of morphine in cancer pain patients

Stephan A. Schug, D. Zech, Stefan Grond et al. · Journal of Pain and Symptom Management · 1992 · 148 citations · Full text

Medicine, Oncology, Pharmacotherapy +14

Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat

Lisa Gold, Luis Stinus, Charles E. Inturrisi et al. · European Journal of Pharmacology · 1994 · 138 citations

Medicine, Pharmacology, Behavioral Pharmacology +15