Concepedia

Phase II Randomized Controlled Trial of an Epidermal Growth Factor Vaccine in Advanced Non–Small-Cell Lung Cancer

Elia Nenínger Vinageras, Ana de la Torre, Marta Osorio Rodríguez, Mauricio Catalá Ferrer, Idania Bravo, Mario Mendoza del Pino, Daniel Abreu Abreu, Soraida Acosta Brooks, Rolando Rives, Concepción del Castillo Carrillo,

Journal of Clinical Oncology · 2008 · 200 citations · 13 references

DOIFull text

Open access

Abstract

Vaccination with EGF was safe and provoked an increase in anti-EGF antibody titers and a decrease in serum EGF. There was a direct correlation between antibody response and survival. There was a direct correlation between decrease in serum EGF and survival. In patients younger than 60 years, vaccination was associated with increased survival.

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