Asymmetric Synthesis of N-(Diphenylphosphinyl)amines Promoted by Chiral Carbosilane Dendritic Ligands in The Enantioselective Addition of Dialkylzinc Compounds to N-(Diphenylphosphinyl)imines - Concepedia

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Asymmetric Synthesis of N-(Diphenylphosphinyl)amines Promoted by Chiral Carbosilane Dendritic Ligands in The Enantioselective Addition of Dialkylzinc Compounds to N-(Diphenylphosphinyl)imines

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2002

Year

Itaru Sato, Kenji Hosoi, Ryo Kodaka, Kenso Soai

European Journal of Organic Chemistry

EngineeringAsymmetric SynthesisOrganic ChemistryChiral DendrimersEnantioselective AdditionStereoselective SynthesisChemistryPharmacologyAsymmetric CatalysisFlexible Carbosilane BackbonesEnantioselective SynthesisBiomolecular EngineeringDialkylzinc Compounds

Abstract

The enantioselective addition of dialkylzinc compounds to N-(diphenylphosphinyl)imines by using chiral dendrimers with flexible carbosilane backbones gives enantiomerically enriched N-(diphenylphosphinyl)amines with up to 92% ee. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)