Publication | Closed Access
What Can a Metal Catalyst Do with Allenes? One‐Step Formation of Steroid Scaffolds from Readily Available Starting Materials
71
Citations
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References
2005
Year
Materials ScienceAsymmetric CatalysisChemical EngineeringEngineeringNatural SciencesDiversity-oriented SynthesisHeterogeneous CatalysisOrganic ChemistrySteroid ScaffoldsOrganometallic CatalysisCatalysisChemistryAvailable AllenesMetal CatalystTransition-metal-catalyzed ReactionsCatalyst PreparationReadily AvailableCatalytic Synthesis
The beauty and power of transition-metal-catalyzed reactions has been demonstrated by the one-step synthesis of steroid scaffolds from readily available allenes. The best results (57–73 % yield) were obtained using trans-[RhCl(CO)(PPh3)2] as the catalyst in toluene (see scheme; E=CN, CO2Me, SO2Ph, Ts=toluene-4-sulfonyl).
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