Direct C–H trifluoromethylation of di- and trisubstituted alkenes by photoredox catalysis

Abstract

A range of multisubstituted CF3-alkenes are easily accessible by photoredox-catalyzed direct C-H trifluoromethylation of alkenes under mild reaction conditions. In particular, trifluoromethylation of triphenylethene derivatives, from which synthetically valuable tetrasubstituted CF3-alkenes are obtained, have never been reported so far. Remarkably, the present facile and straightforward protocol is extended to double trifluoromethylation of alkenes.