Ligand Binding and Activation of PPAR <b>γ</b> by Firemaster ^® 550: Effects on Adipogenesis and Osteogenesis <i>in Vitro</i>

Abstract

Our findings suggest that FM550 components bind and activate PPARγ. In addition, in vitro exposure initiated adipocyte differentiation and antagonized osteogenesis. TPP likely is a major contributor to these biological actions. Given that TPP is ubiquitous in house dust, further studies are warranted to investigate the health effects of FM550.