Stereocontrolled Total Synthesis of Apicularen A and Its Δ17,18 Z Isomer

Abstract

Mimicking nature's biosynthetic pathway to polyketides, a two-step procedure involving allylation followed by ozonolysis was applied five times in total for the construction of the carbon skeleton of apicularen A (1). Application of the developed synthetic technology also establishes an entry into designed apicularen analogues.