Molecules · 1997 · 23 citations · 6 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistryStructure-activity RelationshipsAntibacterial AgentsAntifungal AgentsHeterocyclic ChemistryStructure-activity Relationship AnalysisAntibiotic DiscoveryAntimicrobial Drug DevelopmentCandida Albicans InfectionNatural Antifungal CompoundsNew Antifungal AgentsNovel Antibacterial AgentsNovel Antibacterial Drug Discovery
The synthesis and antimicrobial activity of six new 2-alkenyl-6-aminobenzothiazoles are reported. The new compounds were prepared by alkenylation of the potassium salt of 6-amino-2-mercaptobenzothiazole with alkenyl bromides. The structure of the compounds was verified by 1H NMR spectra. The compounds have shown antibacterial activity against Staphylococcus aureus and anticandidous activity against Candida albicans. The optimum structure of the studied compounds has been calculated by quantum chemistry AM1 method. The theoretical values of lipophilicity were calculated for all alkenyl substituents.
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Anti-<i>Candida</i>activity of four antifungal benzothiazoles
Helena Bujdáková, Tomáš Kuchta, Eva Sidà ová et al. · FEMS Microbiology Letters · 1993 · 60 citations · Full text
T. Kuchta, Katarína Barková, Róbert Kubinec · Biochemical and Biophysical Research Communications · 1992 · 29 citations