Deletion of <i>Phd2</i> in Myeloid Lineage Attenuates Hypertensive Cardiovascular Remodeling

Abstract

Phd2 deletion in myeloid lineage attenuates hypertensive cardiovascular hypertrophy and fibrosis, which may be mediated by decreased inflammation- and fibrosis-associated gene expression in macrophages. PHD2 in myeloid lineage plays a critical role in hypertensive cardiovascular remodeling.