Exploiting the Co-evolution of Interacting Proteins to Discover Interaction Specificity

A Mathematical Theory of Communication

Claude E. Shannon · Bell System Technical Journal · 1948 · 80.7K citations

Engineering, Communication, Electrical Engineering +11

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Julie Thompson, Desmond G. Higgins, Toby J. Gibson · Nucleic Acids Research · 1994 · 64.9K citations · Full text

Life Sciences, Bioinformatics, Sequence Analysis +14

Optimization by Simulated Annealing

Scott Kirkpatrick, C. D. Gelatt, M.P. Vecchi · Science · 1983 · 44.6K citations

Natural Sciences, Mathematics, Algorithms +10

The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999

Amos Bairoch, Rolf Apweiler · Nucleic Acids Research · 1999 · 3.2K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +16

Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

Edward M. Marcotte, Matteo Pellegrini, Ho Leung Ng et al. · Science · 1999 · 1.7K citations

Life Sciences, Bioinformatics, Molecular Biology +15