The Regioselectivity of the Asymmetric Intermolecular Heck Reaction with Planar Chiral Diphosphine–Oxazoline Ferrocenyl Ligands

Abstract

Abstract A series of novel planar chiral diphosphine‐oxazoline ferrocenyl ligands were synthesized and used efficiently in the palladium‐catalyzed asymmetric intermolecular Heck reaction of 2,3‐dihydrofuran with aryl triflate and cyclohexenyl triflate. The tuning of the regioselectivity was realized by means of different palladium precursors and by changing the electronic factor of the ligands. A plausible rationale based on the existed mechanism is provided.