Rapid Determination of Fibronectin by Laser Nephelometry Fibronectin concentrations in plasma in human diseases, I.

Abstract

Fibronectin (Synonyms: cold-insoluble globulin, antigelatin factor) is a cell surface glycoprotein. It has been shown that remarkably large amounts of fibronectin are present in human plasma. Owing to the difficult and expensive radioimmunoassays, only a few reports on the relation of fibronectin and human diseases have so far been published. In this communication a rapid and easily handled immunoassay, using the light scattering effect, is described. The first results on the measurement of fibronectin concentrations in the plasma of patients with chronic active liver diseases are reported.