A Synthetic Metabolic Pathway for Production of the Platform Chemical Isobutyric Acid

Abstract

Go green: Isobutyric acid is a high-volume industrial chemical produced from non-sustainable petroleum feedstocks and toxic materials. A synthetic metabolic pathway is constructed in E. coli to enable the biosynthesis of this compound from glucose, a renewable carbon source. The biosynthetic approach is an attractive option from both an economical and environmental point of view. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.