Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi) - Concepedia

Concepedia

Publication | Closed Access

Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)

162

Citations

39

References

2011

Year

Qiuwei Pan, Vedashree Ramakrishnaiah, Scot D. Henry, Suomi M.G. Fouraschen, Petra E. de Ruiter, Jaap Kwekkeboom, Hugo W. Tilanus, Harry L.A. Janssen, Luc J. W. van der Laan

Abstract

Both human and mouse hepatic cells exchange small silencing RNAs, partially mediated by shuttling of exosomes. Transmission of siRNA potentially extends the therapeutic reach of RNAi-based therapies against HCV as well as other liver diseases.

References

	Year	Citations

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