SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication

TLDR

Impaired gastric accommodation may lead to dyspeptic symptoms. The study aims to evaluate the accuracy of SPECT for measuring gastric volumes, compare it with barostat measurements, provide normal gastric volume data, and assess differences in post‑fundoplication patients. SPECT with three‑dimensional image analysis was used to measure balloon volumes in vitro and simultaneously with gastric barostat to assess total gastric volumes. SPECT accurately measured balloon volumes (R²=0.99), produced post‑prandial/fasting and post‑distension volume ratios comparable to barostat, revealed lower volumes in females, showed no age or BMI effects, demonstrated a reduced post‑prandial/fasting ratio in post‑fundoplication patients, and overall proved a non‑invasive method comparable to barostat for assessing gastric volume changes.

Abstract

<b>Background:</b> Impaired gastric accommodation may lead to dyspeptic symptoms. A non-invasive method using single photon emission computed tomography (SPECT) has been developed to measure gastric volumes. <b>Aims and methods:</b> Our aims were: to assess the accuracy of SPECT with three dimensional image analysis to measure balloon volumes in vitro; to compare gastric barostat balloon volumes measured post-meal and post-distension with total gastric volumes measured simultaneously with SPECT; to present normal gastric volume data for healthy adults; and to compare SPECT data in health with symptomatic post-fundoplication patients. <b>Results:</b> In vitro balloon volumes measured by SPECT were highly accurate (<i>R</i>²=0.99). When measured simultaneously by gastric barostat and SPECT, postprandial/fasting volume ratios (2.2 (0.12) (mean (SEM)) <i>v</i> 2.3 (0.15), respectively; p=0.6) and post-distension volume ratios (1.4 (0.1) <i>v</i>1.3 (0.1); p=0.2) were highly comparable. In females, postprandial gastric volumes (675 (14) <i>v</i> 744 (20) ml for males; p=0.004) and changes in gastric volumes (464 (14) ml <i>v</i> 521 (20) ml for males; p=0.01) measured by SPECT were significantly lower than in males. No effects of age or body mass index were noted. The postprandial/fasting gastric volume ratio by SPECT was lower in post-fundoplication patients (2.7 (0.2)) than in healthy controls (3.4 (0.1); p=0.003). <b>Conclusions:</b> SPECT provides a non-invasive estimate of the effect of a meal on total gastric volume that is comparable to changes in balloon volume observed with the gastric barostat. The SPECT technique is promising for investigation of gastric volumes in health and disease and the effects of pharmacological agents.