Proceedings of the National Academy of Sciences · 1996 · 402 citations · 40 references
Life SciencesBiochemistryCell BiologyApoptosisMitochondrial BiologyRedox BiochemistryMitochondrial BioenergeticsMitochondrial DysfunctionMitochondrial PhysiologyMitochondrial Stress ResponsesOxidative Stress PhysiologyReactive Oxygen SpeciesCellular Heat Shock ResponseHeat Shock ResponseMitochondrial Antioxidant DefenseMitochondrial Cristae FormationMitochondrial Cristae OrganizationMitochondrial Oxidative StressMitochondrial ResponseOxidative Stress Injury
Heat shock (HS) proteins (HSPs) induce protection against a number of stresses distinct from HS, including reactive oxygen species. In the human premonocytic line U937, we investigated in whole cells the effects of preexposure to HS and exposure to hydrogen peroxide (H2O2) on mitochondrial membrane potential, mass, and ultrastructure. HS prevented H2O2-induced alterations in mitochondrial membrane potential and cristae formation while increasing expression of HSPs and the protein product of bcl-2. Protection correlated best with the expression of the 70-kDa HSP, hsp70. We propose that mitochondria represent a selective target for HS-mediated protection against oxidative injury.
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