In Vivo Blockade of Platelet ADP Receptor P2Y ₁₂ Reduces Embolus and Thrombus Formation but Not Thrombus Stability

Abstract

These findings demonstrate that ADP and its P2Y12 receptor are involved in thrombus growth and especially in the formation of emboli on the downstream side of the initial thrombus. This may explain the beneficial effects of P2Y12 receptor antagonists in secondary prevention of ischemic events in patients with arterial thrombosis.