Concepedia

Vimentin is an endogenous ligand for the pattern recognition receptor Dectin-1

Praveena Thiagarajan, Valentin P. Yakubenko, Deena Elsori, Satya P. Yadav, Belinda Willard, Carmela D. Tan, E. René Rodríguez, Maria Febbraio, Martha K. Cathcart

Cardiovascular Research · 2013 · 122 citations · 35 references

DOIFull text

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Abstract

We conclude that vimentin is an endogenous, activating ligand for Dectin-1. Its presence in areas of artery wall inflammation and O₂⁻ production suggests that vimentin activates Dectin-1 and contributes to the oxidation of lipids and cholesterol accumulation in atherosclerosis.

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