Concepedia

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

Pankaj Bhavsar, Mark Hew, Nadia Khorasani, Alfons Torregó, Peter J. Barnes, Ian M. Adcock, Kian Fan Chung

Thorax · 2008 · 247 citations · 34 references

DOIFull text

Open access

Abstract

Alveolar macrophages from patients with severe asthma demonstrate CS insensitivity associated with increased p38 MAPK activation that may result from impaired inducibility of MKP-1.

References

34

Can Guideline-defined Asthma Control Be Achieved?

Eric D. Bateman, Homer A. Boushey, Jean Bousquet et al. · American Journal of Respiratory and Critical Care Medicine · 2004 · 1.6K citations

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Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics

Sally E. Wenzel, Lawrence B. Schwartz, Esther L. Langmack et al. · American Journal of Respiratory and Critical Care Medicine · 1999 · 1.2K citations

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

Wendy C. Moore, Eugene R. Bleecker, Douglas Curran‐Everett et al. · Journal of Allergy and Clinical Immunology · 2007 · 926 citations · Full text

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Neutrophilic Inflammation in Severe Persistent Asthma

Anon Jatakanon, Carina Gabriela Uasuf, Wasim Maziak et al. · American Journal of Respiratory and Critical Care Medicine · 1999 · 848 citations

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The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma

European Respiratory Journal · 2003 · 760 citations · Full text