Japanese Journal of Microbiology · 1968 · 14 citations · 8 references
Life SciencesGeneticsMicrobiologyAntimicrobial ResistanceBacteriologyMicrobial GeneticsAntibacterial ResistanceAntibiotic ResistanceAntibiotic Resistance GeneticsAntibiotic Resistance MechanismsMechanisms Of Antimicrobial ResistanceResistance GenesAntibiotic Resistance GenesChromosomally Encoded Resistance DeterminantsMolecular Drug ResistanceResistance Mechanisms In Gram-positive BacteriaResistance Mechanisms In StaphylococciResistance Mechanisms In StreptococciTetracycline Resistance GenesTetracycline Resistance Plasmids
ABSTRACT It was reported that resistance to tetracycline (TC) in some staphylococcal strains was lost irreversibly without loss of resistance to other drugs when cultured at high temperature, and that the determinant for TC resistance exists on a plasmid. According to the transductional analysis of TC resistance in Staphylococcus aureus E169 it was found that the genes which govern resistance to tetracycline and streptomycin are located close together on a single genetic element. When TC resistance in MS146, one of our stock cultures, was transduced to E169S which had lost TC resistance, TC resistance in transductants was found to be unstable at elevated temperatures. By contrast, TC resistance in transductants MS353 TC r , to which TC resistance was transduced from E169, was indicated to be stable even when cultured at high temperature. From these results, it is strongly suggested that instability of TC resistance in E169 is not accounted for by the genetic properties of the genes which govern TC resistance but those of host cell (E169) itself.
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