Analytical Letters · 1999 · 16 citations · 10 references
PharmacyPharmaceutical AnalysisPharmacologyAnalytical ChemistryAnalytical ToxicologyOcular PharmacologyMethod DevelopmentOcular ToxicologyOphthalmic SolutionsSpectroscopic Analysis Of PharmaceuticalsTopical Ophthalmic MedicationsToxicological Screening Of PharmaceuticalsLinearityLinearity AssessmentUltraviolet-visible DetectionUv-visible Quantitative AnalysisZero-crossing AnalysisZero-crossing Detection
ABSTRACT A rapid first-derivative spectrophotometric method for the simultaneous determination of naphazoline nitrate and tetramethylthionine base in eye drops by using zero-crossing measurements is described. Solutions of this drug combination in water were analysed by measurement of the amplitudes at 257.2 and 247.5 nm, respectively. Good linearity, accuracy, precision and selectivity were found, and the method is proposed for routine quality control purposes.
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