Direct sequencing of the gene for Maryland/German familial amyloidotic polyneuropathy type II and genotyping by allele-specific enzymatic amplification

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

Randall K. Saiki, Stephen J. Scharf, Fred Faloona et al. · Science · 1985 · 9K citations

Medicine, Genetics, Molecular Genetics +17

The Metabolic Basis of Inherited Disease.

Annals of Internal Medicine · 1988 · 7.8K citations

Life Sciences, Genetics, Molecular Genetics +13

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

Ulf Gyllensten · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Structure of prealbumin: Secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å

C. C. F. Blake, Michael J. Geisow, Stuart J. Oatley et al. · Journal of Molecular Biology · 1978 · 794 citations

Life Sciences, Biochemistry, Biophysics +6

Characterization of β-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA

Corinne Wong, Carol E. Dowling, Randall K. Saiki et al. · Nature · 1987 · 505 citations

Life Sciences, Genetics, Molecular Genetics +10