Immune Anti‐N Agglutinin in Human Serum

Abstract

A case of apparent hemolytic transfusion reaction due to presence in serum of anti‐N is reported. The reaction was characterized by demonstration of anti‐N in the patient's serum and MN cells in the offending unit. The patient's phenotype proved to be M. Reasons for reporting this unusual case are: 1) It is believed to be the second instance of hemolytic transfusion reaction due to anti‐N yet reported, and 2) Cases of this type again underscore the ease with which saline agglutinating antibodies can be missed in routine crossmatch practice, unless meticulous attention is paid to examination of microscopic agglutinates after the “immediate spin” technic.