Angewandte Chemie International Edition · 1998 · 702 citations · 0 references
Arylboronic AcidsSuzuki Cross-couplingsChemical EngineeringCross-coupling ReactionAryl ChloridesEngineeringHeterocyclicOrganic ChemistryOrganometallic CatalysisCatalysisAvailable ReagentsChemistrySynthetic ChemistryAsymmetric CatalysisPd-catalyzed Suzuki Cross-couplingsBiomolecular Engineering
From only commercially available reagents a wide array of Suzuki cross-couplings of aryl chlorides with arylboronic acids can be effected in excellent yield [Eq. (a)]. This development provides a general solution to a long-standing limitation of this extremely powerful process-the poor reactivity of inexpensive and readily accessible aryl chlorides. dba=dibenzylideneacetone.