Concepedia

17β-Estradiol Attenuates Hematoma Expansion Through Estrogen Receptor α/Silent Information Regulator 1/Nuclear Factor-kappa B Pathway in Hyperglycemic Intracerebral Hemorrhage Mice

Yun Zheng, Qin Hu, Anatol Manaenko, Yang Zhang, Yan Peng, Liang Xu, Junjia Tang, Jiping Tang, John H. Zhang

Stroke · 2014 · 80 citations · 33 references

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Abstract

E2 treatment prevented hyperglycemia-enhanced HE and improved neurological deficits in ICH mice mediated by ERα/Sirt1/nuclear factor-kappa B pathway. E2 may serve as an alternative treatment to decrease early HE after ICH.

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