PRIOR INDUCTION OF HEAT SHOCK PROTEINS BY A NITRIC OXIDE DONOR ATTENUATES CARDIAC ISCHEMIA/REPERFUSION INJURY IN THE RAT1

Abstract

Prior induction of HSP70 and HO-1 with a relatively low dose of FK administration attenuates ischemia and reperfusion injury, which was due to antioxidant and antiapoptotic activities augmented by such stress proteins. Thus, NO releasers as a pharmacological maneuver may provide an innovative approach for the prevention of ischemia and reperfusion injury.