Concepedia

Highly Enantioselective Conjugate Additions of Aldehydes to Vinyl Sulfones

Aitor Landa, M.A. Maestro, Carme Masdeu, Ángel Puente, Silvia Vera, Mikel Oiarbide, Claudio Palomo

Chemistry - A European Journal · 2009 · 81 citations · 50 references

DOIFull text

Open access

Concepts

Abstract

Joined together, organocatalysts aldehydes and sulfones: A diaryl prolinol silyl ether was found to catalyse efficiently and enantioselectively the conjugate addition of aldehydes to vinyl sulfones (see scheme). The ample synthetic utility of the resulting adducts is illustrated.

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