Bortezomib induces apoptosis and autophagy in osteosarcoma cells through mitogen-activated protein kinase pathway <i>in vitro</i>

Abstract

This study provided new insights into the mechanisms underlying bortezomib-induced apoptosis in human osteosarcoma HOS cells, and suggests that bortezomib could be a potent chemotherapeutic agent in the treatment of osteosarcoma.