Enhanced Production of Mineralized Nodules and Collagenous Proteins In Vitro by Calcium Ascorbate Supplemented With Vitamin C Metabolites

Abstract

In vitro treatment with ascorbate containing vitamin C metabolites enhanced the formation of mineralized nodules and collagenous proteins. Calcium threonate may be one of the metabolites influencing the mineralization process. Identifying factors which facilitate the formation of mineralized tissue has significant clinical ramifications in terms of wound healing and bone regeneration.