Reactivation of Herpes Simplex Virus Type 2 After Initiation of Antiretroviral Therapy

Abstract

The prevalence of HSV-2 shedding and GUD increased significantly after ART initiation, possibly because of immune reconstitution inflammatory syndrome. Acyclovir significantly reduced both GUD and HSV-2 shedding and should be considered to mitigate these effects following ART initiation.