The Diabetic Phenotype in <i>HNF4A</i> Mutation Carriers Is Moderated By the Expression of <i>HNF4A</i> Isoforms From the P1 Promoter During Fetal Development

Abstract

We conclude that isoforms derived from the HNF4A P1 promoter are expressed in human fetal, but not adult, pancreas, and that their presence during pancreatic development may moderate the diabetic phenotype in individuals with mutations in the HNF4A gene.