Publication | Open Access
Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during<i>Trypanosoma cruzi</i>Infection
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Citations
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References
2005
Year
Required Il-12 ArisesTrypanosoma Cruzi InfectionT-regulatory CellImmunologyImmune RegulationPathologyImmunologic MechanismCd4 T Cell ResponsesInnate ImmunityCd1d Antigen PresentationNatural Killer TImmune SystemImmunotherapyNatural Killer CellsImmunological MemoryAutoimmune DiseaseAutoimmunityT Cell ImmunityImmune FunctionCell BiologyInterleukin-12 Are RequiredCellular Immune ResponseMedicine
Mechanisms of natural killer T (NKT)-cell activation remain unclear. Here, we report that during Trypanosoma cruzi infection, interleukin-12 (IL-12) deficiency or anti-CD1d antibody treatment prevents normal activation. The required IL-12 arises independently of MyD88. The data support a model of normal NKT-cell activation that requires IL-12 and TCR stimulation.
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