Factors Affecting Human IgE and IgG Responses to Allergen-Like <i>Schistosoma mansoni </i>Antigens: Molecular Structure and Patterns of in vivo Exposure

Abstract

These studies suggest that IgE antigens Sm22.6 and Sm20.8 are only released to boost antibodies when adult worms die, whilst Sm21.7 and SmDLC1 are released constantly from eggs dying in host tissue. IgE responses to these allergen-like molecules may be influenced by patterns of exposure and the number of EF-hand motifs.