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Growth Hormone Inhibits the 11β-Hydroxysteroid Dehydrogenase Type 1 Gene Promoter Activity via Insulin-like Growth Factor I in HepG2 Cells
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2008
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Intact CellsGene Promoter ActivityGlucocorticoidRedox BiologyOxidative StressInsulin-like Growth FactorMetabolic SignalingHuman MetabolismCell SignalingAlcohol DehydrogenasesSteroid MetabolismHealth SciencesGrowth HormoneBiochemistryEndocrine MechanismAdipose TissueMetabolomicsEndocrinologyGene ExpressionPharmacologyCell BiologyDevelopmental BiologyPhysiologyMetabolic RegulationMetabolismMedicine
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), which is highly expressed in liver and adipose tissue, acts predominantly as an 11β-reductase in intact cells and in vivo, catalyzing the conversion of cortisone (E) to cortisol (F) [1].