TRPV1, but not TRPA1, in Primary Sensory Neurons Contributes to Cutaneous Incision-Mediated Hypersensitivity

Abstract

Our data suggest that enhanced TRPA1 function does not mediate the mechanical hypersensitivity that follows skin-only surgical incision. However, the heat hypersensitivity is dependent on TRPV1, and functional up-regulation of TRPV1 in IB4-binding DRG neurons may mediate the heat hypersensitivity after skin incision injury.