Alterations in AP‐1 and AP‐1 Regulatory Genes during HPV‐Induced Carcinogenesis

Abstract

HPV-mediated transformation is associated with altered AP-1, Notch1, Net and CADM1 transcription. Whereas the onset of deregulated expression of various AP-1 family members became already manifest during the immortal state, a shift in AP-1 complex composition appeared a rather late event associated with tumorigenicity.