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Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes
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2008
Year
Pain MedicinePharmacotherapyRelevant Drug-drug InteractionsExperimental PharmacologyMedicinal ChemistryPharmacological StudyHepatotoxicityPain ManagementHealth SciencesBiochemistryLiver PhysiologyHuman Liver MicrosomesDrug-drug Interaction PotentialPharmacologyDrug-induced Liver InjuryHepatologyHepatitisLiver DiseaseNew Analgesic TapentadolMedicineHepatocellular CarcinomaDrug DiscoveryFresh Human
The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug-drug interactions are likely to occur through either mechanism.