Concepedia

Hydroxy Metabolites of the Alzheimer's Drug Candidate 3-[(2,4-Dimethoxy)Benzylidene]-Anabaseine Dihydrochloride (GTS-21): Their Molecular Properties, Interactions with Brain Nicotinic Receptors, and Brain Penetration

William R. Kem, Vladimir M. Mahnir, László Prókai, Roger L. Papke, Xuefang Cao, Susan LeFrancois, Kristin Wildeboer, Katalin Prókai-Tátrai, Julia Porter-Papke, Ferenc Sóti

Molecular Pharmacology · 2004 · 101 citations · 39 references

DOI

Concepts

References

39

COSMO: a new approach to dielectric screening in solvents with explicit expressions for the screening energy and its gradient

Andreas Klamt, Gerrit Schüürmann · Journal of the Chemical Society Perkin Transactions 2 · 1993 · 9.4K citations

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Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of certain naturally occurring nucleoside antibiotics

Vellarkad N. Viswanadhan, Arup K. Ghose, Ganapathi R. Revankar et al. · Journal of Chemical Information and Computer Sciences · 1989 · 1.1K citations

, , +15

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

C M Flores, S W Rogers, L A Pabreza et al. · Molecular Pharmacology · 1992 · 875 citations

, , +17

A glia-derived acetylcholine-binding protein that modulates synaptic transmission

August B. Smit, Naweed I. Syed, Dick Schaap et al. · Nature · 2001 · 567 citations

, , +14

Amyloid Peptide Aβ<sub>1‐42</sub> Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors

Hoau‐Yan Wang, Daniel H. S. Lee, Coralie B. Davis et al. · Journal of Neurochemistry · 2000 · 433 citations

, , +17