Effect of neighboring groups in macromolecular reactions: Distribution of units

Abstract

Abstract The problem of the complete description of the sequence distribution of units in products of macromolecular reactions is discussed. The exact mathematical solution is proposed based on the muitiplet method and rate constants and including the distribution of reacted units as well as nonreacted units. Various approximate solutions of the same problem, i.e., Markovian approximations of the first, second, and third order and an approach based on the consideration of the kinetics of transformations of the sequences of reacted units (B approximation) are considered. To compare the efficiency of various methods of calculation some characteristics of the distribution of units are estimated following exact and approximate equations at various ratios of rate constants.