A Functional Magnetic Resonance Imaging Study of Social Cognition in Schizophrenia During an Acute Episode and After Recovery

Abstract

This is the first study to the authors' knowledge to use a social cognition paradigm to reveal improved left medial prefrontal cortex activation in schizophrenia after recovery from an acute episode. These results suggest that restored left medial prefrontal cortex activation may mediate improvement of insight and social functioning in patients with schizophrenia.