Standard Versus Continuous Administration of Capecitabine in Metastatic Breast Cancer (GEICAM/2009-05): A Randomized, Noninferiority Phase II Trial With a Pharmacogenetic Analysis - Concepedia

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Standard Versus Continuous Administration of Capecitabine in Metastatic Breast Cancer (GEICAM/2009-05): A Randomized, Noninferiority Phase II Trial With a Pharmacogenetic Analysis

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2015

Year

Miguel Martín, Noelia Martínez-Jáñez, Manuel Ramos, Lourdes Calvo, Aňa Lluch, Pilar Zamora, Montserrat Muñoz-Mateu, Eva Carrasco, Rosalía Caballero, José Á. García-Sáenz,

Abstract

Our study was unable to show noninferiority with the continuous capecitabine regimen (Ccont) compared with the approved intermittent regimen (Cint). Further investigation is required to improve HFS. Polymorphisms in several genes might contribute to interindividual differences in response to capecitabine.