High-Affinity, Slowly Desensitizing GABAA Receptors Mediate Tonic Inhibition in Hippocampal Dentate Granule Cells

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

Dolan B. Pritchett, Harald Sontheimer, Brenda D. Shivers et al. · Nature · 1989 · 1.3K citations

Medicine, Neuroscience, Pharmacology +12

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA _A receptors

Brandon M. Stell, Stephen G. Brickley, Chih‐Yung Tang et al. · Proceedings of the National Academy of Sciences · 2003 · 800 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors.

Stephen G. Brickley, Stuart Cull-Candy, Mark Farrant · The Journal of Physiology · 1996 · 731 citations

Life Sciences, Neurobiology, Neuroscience +17

Pharmacological characterization of a novel cell line expressing human <i>α</i>₄<i>β</i>₃<i>δ</i> GABA_A receptors

N. Brown, Julie Kerby, Timothy P. Bonnert et al. · British Journal of Pharmacology · 2002 · 602 citations · Full text

Medicine, Neurobiology, Pharmacology +17

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor.

Ling Xie, Erik Helmerhorst, Kevin Taddei et al. · PubMed · 2002 · 504 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17