Concepedia

En Route to a Plant Scale Synthesis of the Promising Antitumor Agent 12,13-Desoxyepothilone B

Mark D. Chappell, Shawn J. Stachel, Chul Bom Lee, Samuel J. Danishefsky

Organic Letters · 2000 · 49 citations · 38 references

DOI

Concepts

Abstract

[reaction--see text] Efficient and processable syntheses of key building blocks of the antitumor agent 12,13-desoxyepothilone B (dEpoB) by catalytic asymmetric induction are herein described.

References

38

N-methoxy-n-methylamides as effective acylating agents

Steven Nahm, Steven M. Weinreb · Tetrahedron Letters · 1981 · 1.8K citations

, , +5

The osmium-catalyzed asymmetric dihydroxylation: a new ligand class and a process improvement

K. Barry Sharpless, Willi M. Amberg, Youssef L. Bennani et al. · The Journal of Organic Chemistry · 1992 · 1.5K citations

, , +7

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action

Suzanne B. Buck, Sam F. Victory, Richard H. Himes et al. · 1998 · 983 citations

, , +10

Palladium-catalyzed inter- and intramolecular cross-coupling reactions of B-alkyl-9-borabicyclo[3.3.1]nonane derivatives with 1-halo-1-alkenes or haloarenes. Syntheses of functionalized alkenes, arenes, and cycloalkenes via a hydroboration-coupling sequence

Norio Miyaura, Tatsuo Ishiyama, Hirotomo Sasaki et al. · Journal of the American Chemical Society · 1989 · 547 citations

, , +8

Epothilone A and B—Novel 16‐Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

Gerhard Höfle, Norbert Bedorf, Heinrich Steinmetz et al. · Angewandte Chemie International Edition in English · 1996 · 514 citations

, , +15