PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC‐3 prostate cancer cells

Abstract

Our results using tumors from the PC-3 xenograft model suggest that PKCδ activation increases angiogenic activity in androgen-independent PC-3 prostate cancer cells by increasing NADPH oxidase activity and HIF-1α levels and thus may partly be responsible for increased angiogenesis in advanced prostate cancer.