Concepedia

Deoxycholic acid induces the overexpression of intestinal mucin, MUC2, via NF-kB signaling pathway in human esophageal adenocarcinoma cells

JianTao Wu, Jun Gong, Juan Geng, Yinxue Song

BMC Cancer · 2008 · 45 citations · 39 references

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Abstract

Deoxycholic acid induced MUC2 overexpression in human esophageal adenocarcinoma cells by activation of Nuclear factor-kappaB transcription through a process involving PKC-dependent but not PKA, independent of activation of MAP kinase.

References

39

The American Journal of Physiology

The American Naturalist · 1899 · 5.7K citations

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Induction of MUC2 and MUC5AC Mucins by Factors of the Epidermal Growth Factor (EGF) Family Is Mediated by EGF Receptor/Ras/Raf/Extracellular Signal-regulated Kinase Cascade and Sp1*

Michaël Perrais, Pascal Pigny, Marie‐Christine Copin et al. · Journal of Biological Chemistry · 2002 · 273 citations · Full text

Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin

Kristien M.A.J. Tytgat, Hans A. Büller, Frank J.M. Opdam et al. · Gastroenterology · 1994 · 246 citations

, , +6

Homeodomain protein CDX2 regulates goblet-specific gene expression

Hiroshi Yamamoto, Yun-Qing Bai, Yasuhito Yuasa · Biochemical and Biophysical Research Communications · 2003 · 209 citations

, , +6

NF-κB Activation in Esophageal Adenocarcinoma

Mohamed Abdel-Latif, James M. O’Riordan, Henry J. Windle et al. · Annals of Surgery · 2004 · 203 citations · Full text