Pharmaceutical Nano‐Cocrystals: Sonochemical Synthesis by Solvent Selection and Use of a Surfactant

Abstract

Nanopharmaceutics: Sonochemistry and the use of a surfactant (Span-85) was introduced to generate pharmaceutical cocrystals of nanometer-scale dimensions. This method overcomes the inherent solubility difference between the pharmaceutical agent (caffeine in this case) and the cocrystal former (2,4-dihydroxybenzoic acid; see picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.