Internal tandem duplication and Asp835 mutations of the <i>FMS‐</i>like tyrosine kinase 3 (<i>FLT3</i>) gene in acute promyelocytic leukemia

Abstract

The current study found that ITD or Asp835 mutations of the FLT3 gene were present in 36.4% of patients with APL; however, these mutations had no prognostic impact. FLT3/ITD frequently was associated with S-type PML/RAR alpha and with the M3v form of leukemia.