Cycloisomerization of 1,6‐Dienes Mediated by Lewis Super Acids without Additives: Easy Access to Polysubstituted Six‐Membered Carbocycles

Abstract

The tin salt Sn(NTf2)4 (Tf=trifluoromethanesulfonyl) is an efficient catalyst for the selective and ring-size-specific cycloisomerization of highly substituted 1,6-dienes to give six-membered-ring carbocycles (see scheme; X=C(CO2Et)2, C(CO2Me)2 C(CN)(CO2Et), etc.). This is the first Lewis acid catalyzed cycloisomerization of this type of substrate. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z602020_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.